psychedelics and mental health
A study of mice found that psilocybin altered dendrites, the branch-like structures that extend from a nerve cell and receive input from other cells.
Dendrites form connections through small protrusions known as dendritic spines. And in mice that got psilocybin, the size and number of these spines increased by about 10%, which allowed cells to form new connections.
"When we give mice a single dose of psilocybin, we can see those new connections form within a day," Kwan says. "And then they can last more than a month," which is the equivalent of many months in a human.
New connections are a critical part of the rewiring process known as brain plasticity, which allows the brain to learn and adapt.
"Psychedelics seem to elevate plasticity," Kwan says.
Brain plasticity may explain why a single dose of a psychedelic drug can have a long-lasting impact on disorders like anxiety, depression and PTSD.
"It can be months or years," says Dr. Gitte Knudsen a neurologist from University of Copenhagen in Denmark who spoke at the psychedelics session. "It's a stunning effect."
These long-term effects have been shown with drugs including psilocybin, LSD and DMT (ayahuasca), Knudsen says. In contrast, most existing psychiatric drugs need to be taken every day.
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