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  • psychedelics and depression

    From Sky Psychedelics@21:1/5 to All on Mon Jun 12 00:07:55 2023
    Previous studies by Johns Hopkins Medicine researchers showed that psychedelic treatment with psilocybin relieved major depressive disorder symptoms in adults for up to a month. Now, in a follow-up study of those participants, the researchers report that
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    A report on the new study was published on Feb. 15, 2022 in the Journal of Psychopharmacology.

    “Our findings add to evidence that, under carefully controlled conditions, this is a promising therapeutic approach that can lead to significant and durable improvements in depression,” says Natalie Gukasyan, M.D., assistant professor of psychiatry
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    Over the last 20 years, there has been a growing of research with classic psychedelics — the pharmacological class of compounds that include psilocybin, an ingredient found in so-called magic mushrooms. According to the National Institute on Drug Abuse,
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    For this study, the researchers recruited 27 participants with a long-term history of depression, most of whom had been experiencing depressive symptoms for approximately two years before recruitment. The average age of participants was 40, 19 were women,
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  • From J L@21:1/5 to All on Thu Jun 15 23:00:02 2023
    psychedelics and Depression

    Some types of psychedelic drugs, such as psilocybin and MDMA (ecstasy), have shown promise as therapies for treatment-resistant depression and post-traumatic stress disorder. They appear to work by encouraging the growth of new connections between
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    Exactly how these drugs promote plasticity in the brain has been unclear. If the mechanisms could be understood, it might be possible to develop related drugs that can promote brain plasticity without causing unwanted hallucinogenic effects.

    Previous studies have found that psychedelic drugs encourage plasticity by binding to a cellular receptor in neurons called the 5-hydroxytryptamine 2A receptor (5-HT2AR). But other compounds that bind to 5-HT2AR don’t promote plasticity. These include
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    An NIH-funded research team led by Dr. David Olson from the University of California, Davis previously developed a sensor that could distinguish which drugs that bind to 5-HT2AR have hallucinogenic properties and which don’t. In a new study, the team
    set out to better understand why only certain compounds that bind 5-HT2AR drive plasticity. Their results were published on February 17, 2023, in Science.


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