• Thyroid hormones & the evolution of human life-history patterns

    From [email protected]@21:1/5 to All on Wed Oct 18 08:23:38 2023
    Hierarchies in the energy budget:
    Thyroid hormones and the evolution of human life history patterns
    Stephanie B Levy & Richard G Bribiescas 2023
    Evol.Anthr.32:275-292 doi org/10.1002/evan.22000 open access

    The evolution of human life-history characteristics required dramatic shifts in energy allocation mechanisms, vs our primate ancestors.
    Thyroid hormones are sensitive to energy balance (thyroxine T4, tri-iodo-thyronine T3),
    they are significant determinants for tissue-specific & whole-body metabolic rate MR:
    T3 & T4 are in part responsible for setting the body's overall energy budget, they likely played an important role in the evolution of human life-history patterns.
    We propose:
    the dynamics of mammalian T3 production, uptake & action have evolved:
    does energy allocation prioritize the high demands of brain development & functioning, often at the expense of growth & reproduction?
    We explore the role of thyroid hormone dynamics in the evolution of human encephalization, prolonged childhood & adolescence, long lifespans, reproduction & human aging.

    (note also: iodine is more abundant at the sea-side,
    wading/diving in colder water requires special thermo-insulation? --mv)

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