2C-B (4-Bromo-2,5-dimethoxyphenethylamine), also popularly known as Nexus, Venus, Erox, Synergy, Performax, Toonies, or most known as “pink cocaine” (although it is
not structurally related to cocaine), is chemically classified as a 2C-type phenethylamine
drug with psychedelic and entactogenic properties [1]. It was first synthesized in the.
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1970s for therapeutic purposes, but then abandoned due to the significant gastrointestinal adverse effects. Compared to other more common psychedelic drugs such as LSD,
psilocybin, or 3,4-methylendioxy-N-methyl-amphetamine (MDMA), users described the
effects of 2C-B, in a recent controlled study, as non-threatening nor confusing, that the mind
keeps clear during the visions and there is no hangover thereafter. Many 2C substances
from 2C-Series, such as 2C-B, are listed as Schedule I substances and are considered New
Psychoactive Substances (NPS).
Such substances of the 2C series are phenylethylamine-type drugs and can even be subclassified as dimethoxy-phenylethylamines where they share the following core
structure proposed by Zapata et al, and are referenced in an article from Maurer’s 2C
series.

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