1. Forum
  2. Usenet
  3. MISC.NEWS.INTERNET.DISCUS

  • mitochondrial dysfunction

    From JAB@21:1/5 to All on Tue Jan 9 15:19:01 2024
    A discovery in the muscles of long COVID patients may explain exercise
    troubles

    Hit the gym. Get back in shape.

    That's what many patients with long COVID are told when they talk of
    the crushing fatigue that envelops them after even a light bout of
    physical activity.

    These symptoms of exhaustion, or post-exertional malaise as it's
    called, are a hallmark of long COVID and similar complex illnesses
    like chronic fatigue syndrome or ME/CFS.
    ...
    ...
    By taking biopsies from long COVID patients before and after
    exercising, scientists in the Netherlands constructed a startling
    picture of widespread abnormalities in muscle tissue that may explain
    this severe reaction to physical activity.

    Among the most striking findings were clear signs that the cellular
    power plants, the mitochondria, are compromised and the tissue starved
    for energy.

    "We saw this immediately and it's very profound," says Braeden
    Charlton, one of the study's authors at Vrije University in Amsterdam.

    The tissue samples from long COVID patients also revealed severe
    muscle damage, a disturbed immune response, and a buildup of
    microclots.

    "This is a very real disease," says Charlton. "We see this at
    basically every parameter that we measure."


    https://www.npr.org/sections/health-shots/2024/01/09/1223077307/long-covid-exercise-post-exertional-malaise-mitochondria

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Retrograde@21:1/5 to JAB on Tue Jan 9 23:09:12 2024
    On 2024-01-09, JAB <[email protected]d> wrote:
    Among the most striking findings were clear signs that the cellular
    power plants, the mitochondria, are compromised and the tissue starved
    for energy.
    "We saw this immediately and it's very profound," says Braeden
    Charlton, one of the study's authors at Vrije University in Amsterdam.
    The tissue samples from long COVID patients also revealed severe
    muscle damage, a disturbed immune response, and a buildup of
    microclots.
    "This is a very real disease," says Charlton. "We see this at
    basically every parameter that we measure."

    Each virus gets a little better designed to exploit our weaknesses.
    Sounds like this one is able to really mess us up! And it's evolving of course, and far faster than we are.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From JAB@21:1/5 to [email protected] on Tue Jan 9 17:45:32 2024
    On Tue, 09 Jan 2024 23:09:12 GMT, Retrograde
    <[email protected]d> wrote:

    Sounds like this one is able to really mess us up!

    "My body, my choice," they say, until it hits them.

    There might be a genetic relationship for affected persons.

    a disturbed immune response, and a buildup of
    microclots.

    "Estimates show that more than 65 million worldwide have the
    condition, which encompasses a wide range of symptoms that are
    worsened or appear after initial SARS-CoV-2 infection. But three years
    after the first people with persistent symptoms were documented, there
    is no biomarker for the disease -- no test or swab that can diagnose
    someone with Long COVID."

    https://www.unmc.edu/healthsecurity/transmission/2023/05/16/long-covid-scientists-try-to-unravel-blood-clot-mystery/

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Retrograde@21:1/5 to JAB on Wed Jan 10 02:42:12 2024
    On 2024-01-09, JAB <[email protected]d> wrote:
    On Tue, 09 Jan 2024 23:09:12 GMT, Retrograde
    <[email protected]d> wrote:

    Sounds like this one is able to really mess us up!

    "My body, my choice," they say, until it hits them.

    I'm fine with this. They've made their choice, they can live with it
    (or die with it). 8 Billion angry hairless pink monkeys on this earth,
    a few less won't matter.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From JAB@21:1/5 to [email protected] on Tue Jan 9 21:32:22 2024
    On Wed, 10 Jan 2024 02:42:12 GMT, Retrograde
    <[email protected]d> wrote:

    "My body, my choice," they say, until it hits them.

    I'm fine with this.

    I suspect those 65 million+ worldwide will have a shorter life span,
    which in another way, might be environmentally better.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)