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  • Iron In Intracerebral Hemorrhage

    From ironjustice@21:1/5 to All on Fri Jun 8 08:29:03 2018
    Minocycline attenuates brain injury and iron overload after intracerebral hemorrhage in aged female rats.
    Dai S1, Hua Y2, Keep RF2, Novakovic N2, Fei Z3, Xi G4.
    Neurobiol Dis. 2018 Jun 4. pii: S0969-9961(18)30173-6.
    doi: 10.1016/j.nbd.2018.06.001.

    Abstract
    Brain iron overload is involved in brain injury after intracerebral hemorrhage (ICH). There is evidence that systemic administration of minocycline reduces brain iron level and improves neurological outcome in experimental models of hemorrhagic and
    ischemic stroke. However, there is evidence in cerebral ischemia that minocycline is not protective in aged female animals. Since most ICH research has used male models, this study was designed to provide an overall view of ICH-induced iron deposits at
    different time points (1 to 28 days) in aged (18-month old) female Fischer 344 rat ICH model and to investigate the neuroprotective effects of minocycline in those rats. According to our previous studies, we used the following dosing regimen (20 mg/
    kg, i.p. at 2 and 12 h after ICH onset followed by 10 mg/kg, i.p., twice a day up to 7 days). T2-, T2⁎-weighted and T2⁎ array MRI was performed at 1, 3, 7 and 28 days to measure brain iron content, ventricle volume, lesion volume and brain
    swelling. Immunohistochemistry was used to examine changes in iron handling proteins, neuronal loss and microglial activation. Behavioral testing was used to assess neurological deficits. In aged female rats, ICH induced long-term perihematomal iron
    overload with upregulated iron handling proteins, neuroinflammation, brain atrophy, neuronal loss and neurological deficits. Minocycline significantly reduced ICH-induced perihematomal iron overload and iron handling proteins. It further reduced brain
    swelling, neuroinflammation, neuronal loss, delayed brain atrophy and neurological deficits. These effects may be linked to the role of minocycline as an iron chelator as well as an inhibitor of neuroinflammation.

    KEYWORDS:
    Aging; Ferritin; Heme oxygenase-1; Intracerebral hemorrhage; Iron; Magnetic resonance imaging; Microglia; Minocycline

    PMID: 29879529 DOI: 10.1016/j.nbd.2018.06.001

    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/634q5a

    Man Is A Herbivore!
    http://tinyurl.com/4rq595

    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk

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    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Tom Horne@21:1/5 to ironjustice on Fri Jun 8 18:13:45 2018
    On Friday, June 8, 2018 at 11:29:04 AM UTC-4, ironjustice wrote:
    Minocycline attenuates brain injury and iron overload after intracerebral hemorrhage in aged female rats.
    Dai S1, Hua Y2, Keep RF2, Novakovic N2, Fei Z3, Xi G4.
    Neurobiol Dis. 2018 Jun 4. pii: S0969-9961(18)30173-6.
    doi: 10.1016/j.nbd.2018.06.001.

    Abstract
    Brain iron overload is involved in brain injury after intracerebral hemorrhage (ICH). There is evidence that systemic administration of minocycline reduces brain iron level and improves neurological outcome in experimental models of hemorrhagic and
    ischemic stroke. However, there is evidence in cerebral ischemia that minocycline is not protective in aged female animals. Since most ICH research has used male models, this study was designed to provide an overall view of ICH-induced iron deposits at
    different time points (1 to 28 days) in aged (18-month old) female Fischer 344 rat ICH model and to investigate the neuroprotective effects of minocycline in those rats. According to our previous studies, we used the following dosing regimen (20 mg/
    kg, i.p. at 2 and 12 h after ICH onset followed by 10 mg/kg, i.p., twice a day up to 7 days). T2-, T2⁎-weighted and T2⁎ array MRI was performed at 1, 3, 7 and 28 days to measure brain iron content, ventricle volume, lesion volume and brain
    swelling. Immunohistochemistry was used to examine changes in iron handling proteins, neuronal loss and microglial activation. Behavioral testing was used to assess neurological deficits. In aged female rats, ICH induced long-term perihematomal iron
    overload with upregulated iron handling proteins, neuroinflammation, brain atrophy, neuronal loss and neurological deficits. Minocycline significantly reduced ICH-induced perihematomal iron overload and iron handling proteins. It further reduced brain
    swelling, neuroinflammation, neuronal loss, delayed brain atrophy and neurological deficits. These effects may be linked to the role of minocycline as an iron chelator as well as an inhibitor of neuroinflammation.

    KEYWORDS:
    Aging; Ferritin; Heme oxygenase-1; Intracerebral hemorrhage; Iron; Magnetic resonance imaging; Microglia; Minocycline

    PMID: 29879529 DOI: 10.1016/j.nbd.2018.06.001

    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/634q5a

    Man Is A Herbivore!
    http://tinyurl.com/4rq595

    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk

    I don't know who this shill is but he/she sure earns their fee. I have seen messages hyping this drug all over the place.

    --
    Tommy

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)