Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain
combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Pink Cocaine Stimulants – Ethylone can be potentially dangerous in combination with other stimulants as it can increase one’s heart rateand blood pressure to dangerous levels.
25x-NBOMe & 25x-NBOH
Alcohol – Combining alcohol with stimulantscan be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol’s depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant
wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
DXM – Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylene,
mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
MDMA – Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present